The value of AFP with lectin affinity in diagnosis, differentiated diagnosis, and in assessment of the effectiveness of treatment of HCC
- Author:
Nguyen Hanh Phuc
- Publication Type:Journal Article
- Keywords:
Lectin;
Epithelium;
Cancer;
Epithelial cell;
- MeSH:
alpha-Fetoproteins;
Liver Neoplasms;
Diagnosis;
Therapeutics
- From:Journal of Preventive Medicine
2005;15(5):167-171
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
In this study, the usefulness of the lectin reactive alpha-fetoprotein (AFP-L3) in patients with HCC, CLD and patients with HCC treated by transcatheter oil chemoembolization (TOCE) was examined. AFP-L3 levels were measured by lectins affinity electrophoresis and antibody affinity blotting. After TOCE, 40 HCC patients were classified into two groups: 1st group (n=27 with AFP-L3<15%; 2nd group (n=13) with AFP-L3>15%. Results: The mean value of AFP-L3 in the 110 HCC patients was 54.6+/-23.7%, significantly higher (p<0.001) than the value in CLD (11.2+/-3.1%). When the cut-off level was set 15% for AFP-L3, the sensitivity was 96.4%, and the specificity was 95%. Survival rates after 12 and 18 months for all 27 patients calculated according to the Kaplan-Meier methods were 88.9% and 63% in the 1st group and 38.5% and 15.3% in the 2nd group, respectively. The recurrence of HCC for 1st and 2nd group were 10.2+/-3.5 months and 12.0+/-1.7 months. Conclusions: AFP-L3 is a useful marker for the diagnosis of HCC and for differentiation of increased AFP in HCC and CLD. AFP-L3 could be useful for the evaluation of curability after TOCE.
