Effects of herbal medicine extraction on bone destruction and pain behaviors in rats of bone cancer pain
10.3760/cma.j.issn.1673-4246.2010.01.002
- VernacularTitle:补肾壮骨方药对骨转移癌疼痛大鼠痛行为及骨质破坏的影响
- Author:
Bo DENG
;
Liqun JIA
;
Fuyun GAO
;
Lin RAN
- Publication Type:Journal Article
- Keywords:
Bone cancer pain;
Bushen-Zhuanggu medicine extraction;
Bone destruction
- From:
International Journal of Traditional Chinese Medicine
2010;32(1):7-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate therapeutic effects of Bushen-Zhuanggu medicine extraction on bone destruction in rats bone cancer pain.Methods Rat models of cancer-induced bone pain were established by inoculating MRMT-1 cells into tibia of rats.Behavioral signs indicative of pain including 50%paw withdrawal threshold(von Frey tactile sensitivity test)and thermal withdrawal latency were observed.Pathomorphological changes of tibia were monitored with HE staining.Results In the behavioral tests,herbal medicine treatment attenuated mechanical allodynia and thermal hyperalgesia.Histological examination showed that this treatment inhibited tumor proliferation and preserved the cortical and trabccular bone structure.Conclusion Bushen-Zhuanggu medicine extraction is an anti-nociceptive and bone-preserving agent in rats of bone cancer pain.
