Effects of rosiglitazone on the atherosclerosis and oxidative stress in diabetic rabbits
10.3760/cma.j.issn.1000-6699.2010.01.005
- VernacularTitle:罗格列酮对糖尿病兔动脉粥样硬化形成和氧化应激的影响
- Author:
Li LUO
;
Liyong YANG
;
Changsheng XU
- Publication Type:Journal Article
- Keywords:
Diabetes;
Atheroselerosis;
Rosiglitazone;
Oxidative stress
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(1):17-18
- CountryChina
- Language:Chinese
-
Abstract:
Rosiglitazone was used for intervention of atherosclerosis in diabetic rabbits.The results showed that the intima/medium thickness ratio,cross section area of plaque,and the expressions of NADPH oxidase p22phox,gp91 phox were decreased;while the total anti-oxidative ability was increased after administration of rosiglitazone as compared with the non-intervention group(all P<0.05).Compared with rosiglitazone treatment group,serum hepatocuprein leveI in rosiglitazone prevention group was increased,while serum malonaldehyde level decreased(both P<0.05).This study suggests that rosiglitazone may have the effect of reducing the oxidative stress and the formation of atherosclerotic plaque in diabetics.
