Mechanism of α-lipoic acid in reducing the injury of kidneys in diabetic rats
10.3760/cma.j.issn.1000-6699.2010.01.017
- VernacularTitle:α-硫辛酸减轻糖尿病大鼠肾脏损伤的机制
- Author:
Chunyang ZHANG
;
Junjie ZOU
;
Yongquan SHI
;
Ling XIA
;
Huaiqing WANG
;
Wei QU
;
Zhimin LIU
- Publication Type:Journal Article
- Keywords:
Diabetes;
Kidney;
α-lipoic acid;
Oxidative stress;
Glyeation end products;
advanced
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(1):60-62
- CountryChina
- Language:Chinese
-
Abstract:
The effect and mechanism of α-lipoic acid(ALA)on the injury of kidneys in diabetic rats induced by streptozotocin were investigated.Results showed that ALA decreased the level of oxidative stress,the production of advanced glycation end products(AGE)[(0.087±0.003 vs 0.103 4±0.014)pg/mg protein,P<0.05],and the expression of AGE receptor protein(1.8I±0.04 vs 2.67±0.01,P<0.01)and transforming growth factor-β(TGF-β)mRNA(1.51 4±0.20 vs 2.04±0.08,P<0.05)in renal cortex of diabetie rats,resulting in reduced kidney injury and improved renal function in diabetic rats.
