Epigenetic changes and reprogramming of hepatocellular carcinoma
10.3760/cma.j.issn.1673-4203.2010.02.014
- VernacularTitle:肝细胞癌表观遗传学改变和重编程
- Author:
Lixin LI
;
Qiang HE
;
Dazhi CHEN
- Publication Type:Journal Article
- Keywords:
Heaptocellular carcinoma;
Epigenetics
- From:
International Journal of Surgery
2010;37(2):115-117
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. In ad-dition to genetic alterations, epigenetic inactivation of (tumor suppressor) genes has been recognized as an important and alternative mechanism in tumorigenesis. In recent years, increasing evidence has shown that ep-igenetic silencing of those genes is essential to carcinogenesis and metastasis. Epigenetics include two main forms: histone acetylation and DNA methylation, histone acetylation and DNA hypomethylation can promote gene expression,otherwise, they will inhibit gene expression. It is important to the methylation especially the hypermethylation of the tumor suppressor gene during the hepatocarcinogencsis. The study of epigenetics will be proved valuable for early diagnosis and disease monitoring at hepatocell.
