The effect of GRP78 on cancer
10.3760/cma.j.issn.1673-4203.2010.02.018
- VernacularTitle:GRP78在肿瘤中的作用
- Author:
Zhi XU
;
Kai WANG
;
Mingwen HUANG
- Publication Type:Journal Article
- Keywords:
GRP78;
Cancer;
Growth;
Metastasis;
Drug resistance;
Prognosis
- From:
International Journal of Surgery
2010;37(2):127-130
- CountryChina
- Language:Chinese
-
Abstract:
The glucose-regulated protein78 (GRP78) is a member of the heat-shock protein 70 (HSP70) family and responsible for cellular homeostasis. GRP78 is highly expressed in various tumors. It plays an im-portant role in tumor proliferation, survival, metastasis, and drug resistance. Suppression of GRP78 in tumors could enhance cancer treatment. Inhibition of GRP78 in tumors may provide a noval approach toward cancer therapy.
