Advances of FOXM1 and prospects in the research of tumor

VernacularTitle:FOXM1在肿瘤中的研究进展及应用前景
Author: Tao CHEN ; Yanling CHEN ; Jicheng ZHANG
Publication Type:Journal Article
Keywords: Forkhead box M1; Transcription factor; Tumor
From: International Journal of Surgery 2010;37(2):131-135
CountryChina
Language:Chinese
Abstract: FOXM1 (Forkhead box M1), one factor of the Forkhead family, has three subtypes (FOXM1a, FOXM1b, FOXM1c). The current study focuses on FOXM1b and FOXM1c. FOXM1 regulates transcription of prolifemtion-nssociated genes and plays a vital role in embryogenesis as well as reorgani-zation. Recent studies have shown that FOXM1 is closely related with tumor occurrence and development. Tumors with high expression of FOXM1 are often poorly differentiated, highly malignant, distantly metastat-ic, poorly predicted. FOXM1 has a influence on the tumor proliferation, invasion, metastasis and angiogene-sis through regulating its downstream tumor-related genes. At present, the synthesis and study of the anti-tumor chemicals targeting FOXM1 offer a possibility of the FOXM1 in clinical applications. More and more researchers attach importance to its tumor therapeutic value both at home and aboard. This paper will make a review about the lastest FOXM1 research in oncology.