Effective dose and safety of adenosine triphosphate in inducing dual atrioventricular nodal pathways phenomenon
10.3760/cma.j.issn.1673-4904.2010.01.011
- VernacularTitle:三磷酸腺苷诱发房室结双径路现象的有效剂量及安全性
- Author:
Side LU
;
Shuxia BAI
;
Dongsheng LI
;
Hongkao ZHANG
;
Jijun LIU
;
Lei WANG
- Publication Type:Journal Article
- Keywords:
Atrioventricular nodal;
Dose;
Safety;
Adenosine triphosphate
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(1):30-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effective dose and safety of adenosine triphosphate(ATP) in inducing dual atrioventricular nodal pathways(DAVNP)phenomenon.Methods The ATP(the initial dose was 0.15 mg/kg,incremented 0.10 mg/kg each time)was injected to 40 patients who had slow-fast atrioventricular nodal reentrant tachycardia(AVNRT)through a femoral vein until signs of DAVNP,second-or third-degrec atrioventricular block(AVB)appared.The surface and intracardiac electrocardiogram was recorded consecutively.Results Forty patients of the slow-fast AVNRT had AVB after injecting ATP (16.1±5.8)mg(9-22 mg),29 patients(72.5%,29/40)occurred DAVNP phenomenon,of which 11 (37.9%,11/29)revealed DAVNP phenomenon after injecting ATP 0.15 mg/kg.Seventeen patients had side-effects of dyspnea,dizziness,cough,cardiopalmus and so on,but these side-effects were generally minor,short duration.Forty patients had transient cardiac arrhythmia.Conclusions The incremental low-dose method in inducing DAVNP has higher positive rate.The side-effects of ATP are mostly light and short duration,and can not cause serious consequence.
