RNA interference driven by tumor-specific promoters and targeted therapy of tumor
10.3760/cma.j.issn.1673-422X.2009.12.005
- VernacularTitle:肿瘤特异性启动子驱动的RNA干扰与肿瘤基因靶向治疗
- Author:
Yong WANG
;
Xiaopeng CHEN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Promoter regions;
Genes;
RNA interference
- From:
Journal of International Oncology
2009;36(12):894-896
- CountryChina
- Language:Chinese
-
Abstract:
RNA interference driven by tumor specific promoters has targeted therapeutic effect only in tumor tissue,it is a new method in tumor gene therapy,such as alpha-fetoprotein promoter,human telomerase reverse transcriptase promoter,survivin promoter and etc. This method binds specificity of tumor promoter and high effects of RNAi,and can realize specific and highly killing effects in tumor tissue. RNAi driven by tumor specific promoters plays an important role in tumor oncogene targeted therapy.
