Dyslipidemia and important organ damages in patients with active systemic lupus erythematosus
10.3760/cma.j.issn.1007-7480.2010.01.009
- VernacularTitle:活动期系统性红斑狼疮患者脂代谢紊乱与重要脏器损害的关系探讨
- Author:
Huifang GUO
;
Chenxing PENG
;
Mingfeng ZHANG
;
Fuling SHAO
;
Lixia GAO
;
Qing ZHANG
;
Fengzhen LIU
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus;
systemic;
Hypedipidemias;
Organ damage
- From:
Chinese Journal of Rheumatology
2010;14(1):33-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between dyslipidemia and important organ damage in patients with active systemic lupus erythematosus (SLE) without treatment. Methods Serum sam-ples from 71 active SLE patients and 30 healthy controls were obtained to measure lipid profiles including total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), apolipoproteinA1 (apoA1), apolipoproteinB100 (apoB) and lipoprotein a (LPa). Clinical parameters were recorded. Results The levels of serum TC, TG, LDL, apoB in active SLE patients were higher than those in healthy controls, in contrast,the levels of HDL,apoA1 were much lower (P<0.05 or P<0.01). Patients with important organ damages had longer disease course and elevated levels of serum TC, TG, LDL and apoB concentrations than those without organ damage (P<0.05 or P<0.01), especially in patients with cadiovascular diseases (CVD) (P<0.01). Moreover, these changes in lipid metabolism were positively correl-ated with disease course and negatively with C3 level (P<0.05 or P<0.01). The elevated serum TC and LDL concentrations were negatively correlated with C4 level (P<0.05). Conclusion Severe dyslipidemia is present in active SLE patients.It is correlated with disease course and disease activity. Increased serum TC, TG, LDL and apoB concentrations play key roles in patients with important organ damages.
