Diagnosis of small focal nodular lesions in patients with liver cirrhosis: comparison between contrast-enhanced ultrasound and contrast-enhanced helical CT
10.3760/cma.j.issn.1004-4477.2010.01.005
- VernacularTitle:超声造影与增强螺旋CT诊断肝硬化背景下≤2 cm结节样病灶的比较研究
- Author:
Xiang JING
;
Yanli LIU
;
Xiang ZHANG
;
Chuanshan ZHANG
;
Lei GAO
;
Jianmin DING
;
Yandong WANG
;
Xinmin ZHAO
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Liver cirrhosis;
Carcinoma,hepatocellular;
Tomography,spiral computed
- From:
Chinese Journal of Ultrasonography
2010;19(1):16-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the diagnostic value of contrast-enhanced ultrasound (CEUS) and contrast-enhanced helical CT (CECT) for various small focal nodular lesions (≤2 cm) in patients with liver cirrhosis. Methods Eighty-one small hepatic space-occupying lesions in 72 patients with liver cirrhosis were detected with CEUS and CECT, respectively. The diagnostic performance was calculated by histological results obtained from biopsy or surgery, which was considered as the gold standard, Results Fifty-three of the 81 small nodules were hepatocellular carcinoma, 26 were regenerative nodules and 2 were hemangioma. On CEUS, 51 (96.2%,51/53) HCC were hypervascular during arterial phase. On CECT, 41 (77.4%, 41/53) HCC were hypervascular (P < 0.01).Nodules which appeared by contrast enhancement during the arterial phase and contrast wash-out during the portal/late phase on CEUS or CECT were considered as HCC. The sensitivity, specificity and accuracy were 86.8% (46/53) ,82.1% (23/28) ,and 85.2 % (69/81) in CEUS, and 73.6% (39/53), 92.9 % (26/28), and 80.2 % (65/81) in CECT, respectively. Overall, there was no significant difference between CEUS and CECT in the diagnostic confidence for small hepatic nodules (P >0.05).Conclusions CEUS is superior to CECT in the detection of arterial vascularization for small hepatocellular carcinoma with a diameter ≤2 cm. The ability of CEUS in the characterization of focal nodular lesions in cirrhotic livers is similar to that of CECT.
