The role of inflammation and fibrosis cytokines in the pathogenesis of interstitial lung disease

VernacularTitle:肿瘤坏死因子及转化生长因子在肺间质病变发病机制中的作用
Author: Xiao ZHANG ; Li LIN ; Guangfeng ZHANG
Publication Type:Journal Article
Keywords: Transforming growth factor beta; Tumor neurosis factor-alpha; Lung diseases; interstitial; Connective tissue diseases
From: Chinese Journal of Rheumatology 2010;14(1):13-16
CountryChina
Language:Chinese
Abstract: Objective To study the role of tumor necrosis factor-alpha (TNF-α) and transforming growth factor-beta (TGF-β) in CTD-IDL. Methods mRNAs were extracted from lung tissues and perip-heral blood mononaclear cells (PBMCs) of CTD-ILD patients. RT-PCR was deployed to detect the percentages of TNF-α mRNA, TGF-β mRNAs; and the percentage of TNF-α, TGF-β and fibrosing parameters (hyaluronic acid, HA) was tested in serum by ELISA. The relationship between above laboratory data and image as well as pathological characteristics were analyzed. Results The percentage of TGF-β mRNA in lung tissue and PBMCs. As well as the serum TGF-β and HA increased significantly in those with interstitial lung diseases. On the other hand, the percentage of TNF-α mRNA of these patients did not increase in lung tissues and PBMCs. Conclusion TGF-β plays a role in lung interstitial fibrosis. It may be helpful to understand the degree of fibrosis in lung tissue by detecting lung tissue/PBMCs TGF-β mRNA, serum TGF-β and other fibrosis indicators.