A comparison of different protocols in treatment of infant asthma at severe attack

VernacularTitle:不同治疗方案对婴幼儿哮喘重度发作疗效的对比研究
Author: Zhenghai QU ; Lingling CHU ; Shuang HONG ; Li ZHOU ; Shuyu CHE ; Xiumei LIU
Publication Type:Journal Article
Keywords: Asthma; Treatment outcome
From: Chinese Journal of General Practitioners 2010;9(2):117-119
CountryChina
Language:Chinese
Abstract: Eighty one infants with severe asthma attacks were randomly divided into three groups:budesonide group (budesonide suspension + ventolin inhalation),methylprednisolone group (Ventolin inhalation + intravenous methylprednisoloue) and ventolin group (ventolin inhalation alone).Compared with the pre-treatment,the respiratory rate,heart rate,wheeze score,self-feeling score of three groups were gradually reduced (q=2.96-163.37,P＜0.05 or 0.01).The respiratory rate,heart rate of ventolin group was significantly higher than those of budesonide group (q=3.08,4.10,P＜0.05) and methylprednisolone group (q=3.24,3.34,P＜0.05) 4 h after treatment,wheeze score,self-feeling score of ventolin group was significantly higher than budesonide group (q=5.63-23.63,P＜0.01) and methylprednisolone group (q=6.76-23.72,P＜0.01) 4 and 12 h after treatment.Results indicate that budesonide suspension can achieve the same effect as intravenous methylprednisolone and bronchodilators alone may not effectively control the severe asthma attack in infants.