The relationship between serum S100β, neuron-specific enolase and postoperative cognitive dysfunction in the elderly

VernacularTitle:老年患者术后认知功能障碍与血清S100β及神经元特异性烯醇化酶的关系
Author: Guangming YIN ; Shanglong YAO ; Weidong LIANG
Publication Type:Journal Article
Keywords: Cognitive dysfunction; Postoperative complications; S100β; Neuron-specific enolase
From: Chinese Journal of Behavioral Medicine and Brain Science 2010;19(1):42-43
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between S100β, neuron-specific enolase (NSE) and postoperative cognitive dysfunction(POCD) in the elderly. Methods Cognitive function was evaluated using a battery of nine neuro-psychological tests before operation,at one week after operation. The old people were divided into POCD group(n=121) and normal group(n=439). Their S100β and NSE levels in all group were detected by enzyme linked immunesorbent assay(ELISA) before anesthesia,at the end of surgery and 6h,24h after opera-tion. Meanwhile relativity between S100βand NSE levels and factors of postoperative cognitive dysfunction were an-alyzed. Results S100βand NSE levels increased significantly at the end of surgery in both groups, but the levels in normal group were significantly lower than those in POCD group at the same stage(P<0.05). S100β and NSE levels were obviously relative to POCD. Conclusion S100β and NSE levels have close correlation with POCD in the elderly.