Comparison of WHO 2004 and WHO 1973 pathological grading system of non-muscle invasive urothelial neoplasms
10.3760/cma.j.issn.1000-6702.2010.02.011
- VernacularTitle:非浸润性膀胱尿路上皮癌不同病理分级方法的临床应用价值比较
- Author:
Junxing CHEN
;
Bin HUANG
;
Lingwu CHEN
;
Shaopeng QIU
;
Xiaofei LI
;
Wei CHEN
;
Yuping DAI
;
Yueyou LIANG
;
Daohu WANG
;
Yu CHEN
;
Rongpei WU
;
Lihong CHE
- Publication Type:Journal Article
- Keywords:
Bladder neoplasms;
Pathological grading;
Clinical application
- From:
Chinese Journal of Urology
2010;31(2):104-106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare WHO 2004 and WHO 1973 pathological grading methods of non-muscle invasive urothelial neoplasms. Methods The clinical pathological features of 160 non-muscle invasive urothelial neoplasms patients, treated in our hospital from February, 1998 to Decem-ber, 2008, were re-graded according to WHO 2004 and WHO 1973 classification system. To evaluate recurrence and progression of all the patients during the follow up period, we used statistical method to analyses the differences between two classification system. Results There were 160 patients, ac-cording to WHO 1973 classification methods: 5 cases of papilloma, 52 cases of grade 1 tumors, 83 ca-ses of grade 2 and 20 cases of grade 3;By WHO 2004 classification method: 7 cases of papilloma, 31 cases of low-grade malignant potential of urothelial papilloma, 99 cases of low-grade papillary urotheli-al carcinoma and 23 cases of high-grade papillary urothelial carcinoma. There was no difference in re-currence among the grades of WHO 2004 and WHO 1973 pathological grading system (both P>0.05). Regarding the progress of non-muscle invasive papillary urothelial neoplasms, no significant difference was found among grades of WHO 1973 classification system(P>0.05)while difference exis-ted among grades of WHO 2004 pathological grading system (P<0.05), especially between papillary neoplasm of low malignant potential (PNLMP) and high grade papillary urothelial carcinomas(HG-PUC) (P<0.01). Moreover, HGPUC grade had more progression rate (30.4%) than G_3 grade (15.0%). Conclusions Compare to G_3 grade, HGPUC grade was more easily to make progress in pa-tients,due to this grade include more high malignant papillary urothelial carcinomas. Therefore, it is necessary for urologists to use a more rigorously follow up and therapy method in connection with HG-PUC grade of new classification system.
