Effect of estrogen on pathogenesis of osteoporosis in women with maintenance hemodialysis
10.3760/cma.j.issn.1000-6699.2010.02.004
- VernacularTitle:雌激素对维持性血透妇女患者骨质疏松的影响
- Author:
Hua SHANG
;
Yousheng YIN
;
Xiaoli LI
;
Yong HE
;
Weijia QIU
;
Yilan DENG
;
Xiaohong LI
;
Kanghui LI
- Publication Type:Journal Article
- Keywords:
Estrogen;
Maintenance hemodialysis;
Osteoporosis
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(2):108-110
- CountryChina
- Language:Chinese
-
Abstract:
To explore the effect of estrogen on pathogenesis of osteoporosis in women with maintenance hemodialysis. One hundred and twenty women aged 18-45 years had been undergoing maintenance hemodialysis for ≥ 3 months were included. Of them ,60 women without osteoporosis served as control group and the other 60 women with osteoporosis as observation group. Serum concentrations of estradiol, tumour necrosis factor-α (TNF-α), parathyroid hormone (PTH), and calcium were determined, meanwhile bone mineral density (BMD)was measured by quantitative computed tomography. Serum estradiol levels in the observation group were lower while TNF-α level were higher than those in control group (all P<0. 05). PTH and calcium levels were not significantly different (P= 0.567 and P = 0. 588). In the observation group, linear correlation analysis revealed positive correlation (r = 0. 865 ,P<0. 01)between estradioi and BMD,while multiple linear regression analysis showed that serum estradiol and calcium levels were positively correlated with BMD, and the concentrations of TNF-α and PTH were negatively correlated with BMD (F= 140.32 ,P<0.01). Estradiol levels were found to have greater effect on BMD(t=5. 386, P<0. 01). Lowered serum concentration of estradiol in women with maintenance hemedialysis seems to be a major factor related to osteoporosis,it accelerates the pathogenesis of osteoporosis by modulating TNF-α.
