Study on adiponectin levels in non-obese first-degree relatives of patients with type 2 diabetes
10.3760/cma.j.issn.1000-6699.2010.02.006
- VernacularTitle:2型糖尿病家系非糖尿病正常体重一级亲属脂联素水平5年随访
- Author:
Fang WANG
;
Jun LIU
;
Heyuan DING
;
Li SHENG
;
Zaoping CHEN
;
Yulin GUO
;
Xiaohuan LIAO
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Adiponectin;
Intima-media thickness of the common carotid artery
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(2):114-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the adiponectin levels in non-obese first-degree relatives (FDR)of type 2 diabetic subjects and its relation to insulin sensitivity and the intima-media thickness of the common carotid artery (IMT) during 5-year follow-up. Methods Fifty-three FDR subjects and 37 control subjects who were free of type 2 diabetes were enrolled. Plasma adipenectin, lipid profile, blood glucose, fasting insulin, and blood pressure were determined at baseline and after 5-year follow-up. IMT and endothelial-dependent vasodilation (EDVD) were measured by high-resolution B-mode ultrasound imaging. Homeostasis model assessment was used to evaluate insulin resistance (HOMA-IR)and β-cell function (HOMA-β). 29 FDR subjects and 20 control subjects completed the follow-up. Results Comparing with the control, plasma adiponectin levels in non-obese FDR subjects were lower at baseline [(10.06±5.79)vs (14.43±7.91) mg/L, P< 0.05]. Plasma adiponectin were decreased 24.0% in non-obese FDR and 36.7% in control duning 5 year follow-up (both P<0.05). Adiponectin levels were negatively correlated with waist-to-hip ratio (r = -0. 397), fasting blood glucose (r = -0. 373), IMT (r = -0. 372), and HOMA-IR (r=-0. 40)in the non-obese FDR. After adjusting other relevant risk factors,adiponectin was associated with age, high-density lipoprotein-cholesterol, and IMT in multiple regression analyses in non-obese FDR group. In the control group, a similar analysis revealed that low-density lipoprotein-cholesterol and IMT explained 25% of the variability in the adiponectin concentration. Conclusion Plasma adiponectin levels were decreased after 5 years in both non-obese FDR and control subjects. Decreased adiponectin level may be related to IMT increment.
