Expression of MMP-9, TIMP-1, and NF-κB in papillary thyroid carcinoma and its significance
10.3760/cma.j.issn.1000-6699.2010.02.011
- VernacularTitle:MMP-9、TIMP-1和NF-κB在甲状腺乳头状癌中的表达及意义
- Author:
Jianhua SHI
;
Wanying WANG
;
Yang LI
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase-9;
Tissue inhibitor of metalloproteinnse-1;
NF-κB;
In situ hybridization;
Immunohistochemistry
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(2):129-131
- CountryChina
- Language:Chinese
-
Abstract:
The expressions of matrix metalloproteinnse-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1) ,and NF-κB in 157 cases of papillary thyroid cancer and 30 cases of papillary thyroid tumors were detected by immunohistochemistry and in situ hybridization. The expressions of MMP-9 and NF-κB protein and mRNA in papillary thyroid cancers were significantly higher than those in benign tumors (all P <0.01), and increased according to the pathological grading (P<0.01). The expressions of MMP-9 and NF-κB protein and mRNA in papillary thyroid cancers with cervical lymph node metastasis were higher than those without metastasis (both P <0.01). The expressions of TIMP-1 protein and mRNA appeared an opposite direction of MMP-9 expression.
