The mechanism of the effect of glucagon-like peptide-1 on injury to neonatal rat cardiomyocytes induced by hypoxia-reoxygenation

VernacularTitle:胰升糖素样肽1对乳鼠心肌细胞缺氧/复氧损伤的保护机制
Author: Yun XIE ; Weiwei SHA ; Xue ZHOU ; Shaoxin WANG ; Weilin WANG ; Liping HAN ; Jiachi WANG ; Demin YU
Publication Type:Journal Article
Keywords: Glucagon-like poptide-1; Hypoxia-reoxygenation; Apoptosis; Caspase-3
From: Chinese Journal of Endocrinology and Metabolism 2010;26(2):146-147
CountryChina
Language:Chinese
Abstract: To study the possible mechanism of the effect of glucagon-like peptide-1 (GLP-1) on injury to neonatal rat cardiomyocytes induced by hypoxia-reoxygenation. Lactate dehydrogenase activity [(210.0±11.5) vs (101.4±6.5) U/L] ,apoptosis rate [(8. 138±1. 512) vs(0. 575±0. 168)%] ,and caspase-3 activity [(44.52± 5.69)vs(19.98±1.97) ,all P<0.01] were all increased after hypoxia-reoxygenation. GLP-1 appears to directly act on cardiomyocytes and to protect them from hypoxia-reoxygenation injury [lactate dehydrogenase (190.2±9.0) U/ L, apoptosis rate (2.688±0.580) %, caspase-3 activity 30.34±4.18] mainly by inhibiting the apoptosis probably via the PBK/Akt signaling pathways.