Effects of glimepiride on plasma glucose and beta-cell function in newly diagnosed type 2 diabetic patients
10.3760/cma.j.issn.1008-6706.2010.01.007
- VernacularTitle:格列美脲对初诊2型糖尿病患者血糖控制及胰岛β细胞功能的影响
- Author:
Jiaoe ZENG
;
Shangxia NING
;
Jingli WANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus;
type 2;
Glimepiride;
Insulin;
Pancreatic beta-cell
- From:Chinese Journal of Primary Medicine and Pharmacy
2010;17(1):16-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of glimepiride and short-term intensive therapy with insulin on plasma glucose and beta-cell function in newly diagnosed type 2 diabetic patients.Methods 80 newly diagnosed type 2 diabetic patients were divided into two groups of 40 patients each and randomly treated with insulin or glimepiride plus metformin for 8 weeks.The FBG,2hPBG,HbA_1c,improvement of beta-cell function were measured before and after intensive therapy in each group.Results After the treatment,FBG,2hPBG,HbA_1c were significantly decreased (all P<0.001) in each group;FCP and 2hPCP were increased(P<0.05)in each group.Conclusion Glimepiride or short-term intensive therapy with insulin plus metformin could effectively improve glycemic control and beta-cell function in newly diagnosed type 2 diabetic patients.