The clinical features in chronic severe hepatiti B patients with HBeAg-positive and HBeAg-negative
10.3760/cma.j.issn.1008-6706.2010.01.024
- VernacularTitle:HBeAg阳性与HBeAg阴性慢性重型乙型肝炎死亡患者的临床特征比较
- Author:
Bin WEN
;
Jing YUAN
;
Xiaohe LI
;
Mindong HU
;
Jiaohong ZHANG
;
Ming WU
- Publication Type:Journal Article
- Keywords:
Hepatms B;
chronic;
Hepatitis B e antigens;
DNA;
virus
- From:Chinese Journal of Primary Medicine and Pharmacy
2010;17(1):50-52
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics in chronic severe hepatitis B patients with HbeAg-positive and HbeAs-negative.Methods A total of 95 chronic severe hepatitis B cases were retrospectively analyzed.The clinical information,hepatic function,hepatic fibrosis and HBV DNA in HBeAg-negative and HBeAgpositive groups were analyzed.Results of the 95 cases,54(57% ) were HBeAg-negative and 41(43% ) were HBeAg-positive.No significant differences were found on age,ALB,TB,CHE,indexes of hepatic fibrosis and the ratio of complications between HBeAg-negative group and HBeAg-positive group.Compared with HBeAg-positive group,there were significantly higher levels of ALT(198.25±215.37)U/L vs(400.37±413.59)U/L],AST[(254.78±269.16)U/L vs(578.14±600.23)U/L] and lower level of HBV DNA[(6.17×10~6±8.24×10~1)copies/ml vs (2.39×10~5±6.75×10~1) copies/ml] in HBeAg-negative group(P<0.05).The anteroposterior diameter of the left liver and the thickness of right liver were(65.12±12.43)mm and(95.37.±12.69)mm in the HBeAg positive fatal chronic severe hepatitis B before the terminal phase,vs(56.78±11.04)mm and(89.34.±9.23)mm in the HBeAg negative group,and the former is longer than the later(P<0.05).Conclusion Tissue injury is more serious and the level of HBV DNA is lower in HBeAg-negative patients than HBeAg-positive patients.Liver size of HBeAg negative group reduces more significantly than HBeAg positive group before terminal phase.
