Effect of high glucose environment on the NF-κB/Iκ B signal pathway in cultured rat glomerular mesangial cell and its mechanism
10.3760/cma.j.issn.1000-6699.2010.02.019
- VernacularTitle:高糖环境对肾系膜细胞NF-κB/IκB通路的影响及其调控机制
- Author:
Ling XU
;
Jia LI
;
Lan JIANG
;
Yong XU
;
Haihua ZHONG
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathy;
High glucose;
NF-κB;
MG132;
Ubiquitin-proteasome pathway
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(2):152-154
- CountryChina
- Language:Chinese
-
Abstract:
To explore the effect of high glucose on the NF-κB/IκB signal pathway in cultured rat glomerular mesangial cells. The results showed that high glucose increased the degradation of IκB-α and the translocation to nucleus of NF-κB. These changes could be reverted mostly by MG132, a proteasome inhibitor. It suggests that the activation of the NF-κB signal pathway by high glucose concentration may probably be via the ubiquitin-proteasome pathway.
