Clinical analysis of venous thromboembolism with Wegener's granulomatosis
10.3760/cma.j.issn.1007-7480.2010.02.012
- VernacularTitle:韦格纳肉芽肿病合并静脉血栓临床分析
- Author:
Limin ZHANG
;
Qingjun WU
;
Guohua ZHANG
;
Xiaofeng ZENG
- Publication Type:Journal Article
- Keywords:
Wegener's granulomatosis;
Venous thrombosis;
Risk factors
- From:
Chinese Journal of Rheumatology
2010;14(2):107-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the prevalence of VTE in wegener's granulomatosis(WG)and its relation with disease activity as well as the risk factors.Methods Patients diagnosed with WG between 2000 and 2008 were included.Retrospective,systematic analysis and comparison were made between the characteristics of patients in the venous thromboembolism(VTE)group and non-VTE group.Results Seyenty-onepatients with WG were included.Seven VTEs(2 pulmonary emboli.5 deep venous thromboses)occurred in association with WG,all occurred during active phase of the disease.The prevalence of VTE was 9.8%.According to univariate analysis,male sex,nephritic range proteinuria(24 h)≥3.0 g and elevated serum creatinine were significantly associated with VTE.There were no significant differences in classic risk factors between patients with and without WG-associated VTE.Conclusion Patients with WG have an increased risk of developing VTEs.especially when WG is active.Male sex,nephritic range proteinuria(24 h)≥3.0 g and elevated sernm creatinine are risk factors.Clinicians taking care of patients with WG should be highly aware of the risks for VTE and maintain a low threshold for evaluating patients for possible deep venous thrombosis or pulmonary embolism.
