Sirolimus conversion in liver transplant recipients with calcineurin inhibitor-related renal insufficiency after liver transplantation
10.3760/cma.j.issn.1007-8118.2010.02.011
- VernacularTitle:西罗莫司在肝移植术后钙调素类抑制剂相关肾损病人中的应用
- Author:
Weiqiang JU
;
Xiaoshun HE
;
Dongping WANG
;
Linwei WU
;
Qiang TAI
;
Anbin HU
;
Ming HAN
;
Xiaofeng ZHU
;
Jiefu HUANG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Sirolimus;
Calcineurin inhibitor;
Renal insufficiency
- From:
Chinese Journal of Hepatobiliary Surgery
2010;16(2):112-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of sirolimus in treating calcineurin inhibitor-related renal insufficiency after liver transplantation. Methods Eleven patients with calci-neurin inhibitor-related renal insufficiency after liver transplantation received sirolimus conversion.Simultaneously, the dose of tacrolimus was decreased or tacrolimus was withdrawn. Blood creatinine,sirolimus level, tacrolimus level, liver function, rejection episodes and drug side-effect were moni-tored. Results All the 11 patients survived today with 6 to 20 months of follow-up. All patients showed improvement of renal function after conversion to sirolimus. Blood creatinine level was reduced from (163.8±47.9)μmol/L to(108.1±26.6)μmol/l. (P<0.05). One patient's liver function had an acute rejection episode that was successfully treated with increase of dose of tacrolimus. The side-effects of sirolimus included hyperlipidemia (4 patients), anaemia (1) and mouth ulcers (2).Conclusion Siolimus can be effectively and safely used in liver transplant recipients suffering from ta-crolimus-related renal insufficiency.
