Clinical implication of thyroid peroxidase antibody detection
10.3760/cma.j.issn.1000-6699.2010.02.027
- VernacularTitle:甲状腺过氧化物酶抗体检测的临床意义
- Author:
Chao LIU
;
Lili CHEN
;
Jixiang DONG
- Publication Type:Journal Article
- Keywords:
Thyroid peroxidase antibody;
Autoimmune thyroid disease;
Hashimoto disease;
Detection(
- From:
Chinese Journal of Endocrinology and Metabolism
2010;26(2):171-174
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid peroxidase (TPO) , originally described as thyroid microsomal antigen, is present on the apical surface of thyroid follicular cells and is an antigen involved in cell mediated cytotoxicity. TPO evokes high-affinity, IgG-class autoantibodies (TPOAbs) and TPO-specific T cells that are markers of thyroid infiltration or implicated in thyroid destruction, respectively. Enzyme-linked immunosorbent assay is used most frequently for TPOAb detection and quantification. The other conditions associated with TPOAbs include pernicious anemia, connective tissue disorders, diabetes, inflammatory bowel disease, mood disorders, and fertility-related problems such as miscarriage, infertility, in vitro fertilization failure, pre-term delivery, and postpartum thyroiditis. The detection of TPOAhs is recommended in the investigation of goitre, diagnosis of Graves' disease and Hashimoto's thyroiditis, and the prediction of risk of developing hypothyroidism during subclinical thyroid disease.
