Fc receptor like 3 in Han nationality of Anhui patients with rheumatoid arthritis

VernacularTitle:FcRL3基因与安徽籍汉族类风湿关节炎的相关性研究
Author: Daoqian SANG ; Zhijun LI ; Linjie CHEN ; Jingming DUAN
Publication Type:Journal Article
Keywords: Arthritis,rheumatoid; Polymorphism,single nucleotide; Haploidy
From: Chinese Journal of Rheumatology 2010;14(2):123-127
CountryChina
Language:Chinese
Abstract: Objective To investigate the association between a few single nucleotide polymorphisms (SNPs)in Fc receptor like 3(FcRL3)and rheumatoid arthritis(RA)in Han nationality of Anhui patients.Methods One hundred and forty RA patients along with one hundred and eighty-seven healthy controls were included in the study.SNPs of FcRL3-1(rs0158440),FcRL3-2(rs2225828),FcRL3-3(rs7528684).FcRL34(rs11284799),FcRL3-5(rs945635),FcRL3-6(rs3761959),FcRL3-7(rs2210913),FcRL3-8(rs2282284)and FcRL3-9(rs2282283)in the FcRL3 gene were genotyped by MALDI-TOF technology.Haplotypes were estimated using PHASE v 2.1 software.Results The frequency of FcRL3-3-1 69C alleles in RA patients was significantly increased compared with healthy controls(X~2=7.348,P=0.007,OR=1.558,CI:1.130～2.150).The decreased compared with healthy controls.ConclusionFcRL3 may be associated with RA susceptibility in Anhui Han population.