Expression of COX-2, MMP-2 and TIMP-2 in human breast cancer

VernacularTitle:乳腺癌环氧合酶-2和基质金属蛋白酶-2及其抑制因子的表达
Author: Zhenzhong YANG ; Xiaonan WANG ; Wei JIANG ; Qiang ZOU ; Mingqiang LIU ; Qiang WU ; Zhengsheng WU
Publication Type:Journal Article
Keywords: Breast cancer; COX-2; MMP-2; TIMP-2; Immunohistochemistry
From: Clinical Medicine of China 2010;26(2):172-175
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of COX-2,MMP-2 and TIMP-2 ,the pathological fea-tures ,and their relationship in breast cancer. Methods The expressions of COX-2 ,MMP-2 and TIMP-2 were deter-mined by S-P immunohistochemical method on tissue chips,which containing 127 cases of breast carcinoma. Results The positive rates of COX-2,MMP-2 and TIMP-2 protein were 81.1 (103/127)% ,96.9(123/127)% and 60.6 (77/127) % respectively;The expression of COX-2 was positively related to auxiliary lymph node metastasis and TNM staging (P<0.01 and P<0.05, respectively), and inversely related to PR expression (P<0.05). Further-more,the expression of COX-2 was positively correlated with MMP-2 (r=0. 290 ,P<0.01). Conclusions The ex-pression of COX-2 might be closely related to the invasion and metastasis of breast cancer and has a close relation-ship with MMP-2. The levels of MMP-2 might be partly regulated by COX-2.