Differential diagnostic value of soluble epithelial cadherin in malignant and benign ascites

VernacularTitle:检测可溶性上皮型钙黏附蛋白对良恶性腹水的鉴别诊断价值
Author: Shaoping LIU ; Weiguo DONG ; Hesheng LUO ; Chunhua FANG ; Yahua HU ; Xianfeng ZHANG
Publication Type:Journal Article
Keywords: Ascites; Diagnosis,differential; Cadherins
From: Chinese Journal of Postgraduates of Medicine 2010;33(4):24-26
CountryChina
Language:Chinese
Abstract: Objective To study the differential diagnostic value of soluble epithelial cadherin (sE-cad) in malignant and benign ascites. Methods The concentrations of sE-cad and carcino-embryonic antigen (CEA) in abdominal cavity synovia patients with benign diseases (31 cases), benign ascites(82 cases) and malignant ascites(119 cases) were ineasured by ELISA technique. Results The concentrations of sE-cad and CEA in malignant ascites patients were significantly higher than those in benign ascites patients and abdominal cavity synovia patients (P < 0.01). The sensitivity, negative predictive value and totally accurate rate of sE-cad was 89.9%, 86.8% and 92.5% respectively,which was significantly higher than those of CEA(68.1%, 65.8% and 76.6%)(P < 0.05). sE-cad in malignant ascites showed a certain tissue specificity. Conclusion sE-cad is an useful tumor marker in differential diagnosis of benign and malignant ascites.