Study on the efficacy of breviscapine in the treatment of vascular cognitive impairment

VernacularTitle:灯盏花素治疗血管性认知功能障碍的疗效观察
Author: Limin WANG ; Lijuan WANG ; Zhonglin LIU ; Enxiang TAO
Publication Type:Journal Article
Keywords: Dementia,vscular; Breviscapine
From: Chinese Journal of Primary Medicine and Pharmacy 2010;17(2):148-149
CountryChina
Language:Chinese
Abstract: Objective To investigate the efficacy of breviscapine in the treatment of vascular cognitive impairment.Methods A self-controlled trial was carried out in 36 patients with vascular cognitive impairment.36 cases were treated with breviscapine injection 50mg intravenous infusion daily for 3 weeks.At the same time,all cases were also given citicoline 0.75g/d and enteric-coated aspirin 100mg/d as routine treatment.The means of the evaluation on therapeutic effect included MMSE and ADL,and the adverse reactions were also observed.Results After the treatment,the MMSE scales increased from(18.75 ± 3.25)to(21.62 ± 3.58)(t=2.52,P＜0.05),Meanwhile,ADL scales declined from(45.65 ±3.36)to(42.33 ±4.18)(t=3.71,P＜0.05).There was significant difference on the MMSE and ADL between the pre and post therapy.No obvious side effects were found.Conclusion The results indicated that the breviscapine injection is an effective medicine in the treatment of vascular cognitive impairment,while the adverse reactions were few.