The expression and meaning of TGF-β and TGIF in endometrosis
- VernacularTitle:TGF-β和TGIF与子宫内膜异位症关系的研究
- Author:
Chenlin PEI
;
Yi ZHANG
;
Furong DAI
- Publication Type:Journal Article
- Keywords:
Transforming growth factor beta/ME;
Endometriosis/ME
- From:
Journal of Chinese Physician
2009;11(9):1180-1182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of TGF-βand TGIF in the pathogenesis of endometriosis. Methods The expression of TGF-β and TGIF was detected by immunohistochemistry method in the ectopic and eutopic endometrium of 30 cases with endometriosis (ec-topic endometrium group and eutopic endometrium group) and in the normal endometrium of 40 cases without endometriosis (control group). Result The expression of TGF -β in ectopic endometrium group was significantly higher than that in eutopic endometrium group and control group (P < 0.05). There was no significant difference in the expression of TGF- βbetween eutopic endometrium group and control group(P > 0.05). The expression of TGIF in ectopic endometrium group was significantly lower than that in eutopic endometrium group and control group( P <0.05). There was no significant difference in the expression of TGIF between eutopic endometrium group and control group(P > 0.05). There were negative correlation between the expressions of TGF - β and TGIF in ectopic endometrium group and eutopic endome-trium group(rs= - 0.769, - 0.549, P < 0.05). Conclusion The abnormal expression of TGF-β and TGIF in ectopic endometrium of pa-tients with endometriosis may be associated with the genesis and progression of endometriosis.
