Specific anti-moesin antibodies can predict associated connective tissue diseases pulmonary involvement
10.3760/cma.j.issn.1007-7480.2010.02.006
- VernacularTitle:特异性抗膜突蛋白抗体在结缔组织病肺部受累早期诊断中的意义
- Author:
Jiuliang ZHAO
;
Mengtao LI
;
Qian WANG
;
Zhuang TIAN
;
Lei YIN
;
Jianguo HE
;
Fengchun ZHANG
;
Yan ZHAO
;
Xiaofeng ZENG
- Publication Type:Journal Article
- Keywords:
Autoantibodies;
Connective tissue disease;
Hypertension,pulmonary;
Lung diseases,interstitial
- From:
Chinese Journal of Rheumatology
2010;14(2):88-90
- CountryChina
- Language:Chinese
-
Abstract:
Objective Immune and inflammatory mechanisms could play a significant role in genesis or progression of interstitial lung disease and pulmonary arterial hypertension,especially in patients with connective tissue diseases.Specific antibodies may predict the occurrence of this condition.Methods The plasma of patients with systemic sclerosis(SSc)or mixed connective tissue disease(MCTD)were screened with enzyme linked immunoserbent assay(ELISA)and Western blotting using recombinant mocsin.The clinical data were recorded and pulmonary function tests(PFTs)were performed in 78 consecutive individuals in order to identify the difference in clinical manifestations between anti-mocsin positive group and negative group.Results Our results showed high titers of anti-mocsin antibodies in 21(53%)of 40 patients with SSc,and 15(39%)of 38 patient with MCTD.The presence of anti-moesin antibodies was significantly correlated with pulmonary involvement(ILD and PAH)in SSc and MCTD patiens(P=0.001).Comparing with the antibody negative group,the total lung capacity[(82±10)% vs(90±14)%,P=0.027),forced vital capacity [(76±13)% vs(85±17)%,P=0.040]and diffu-sing capacity of the lung for carbon monoxide[(58±16)% vs (72±23)%,P=0.014]of PFTs in anti-moesin antibodies positive group were noted to be significantly decreased(P＜0.05).Conclusion Specific antibodies to moesin is prevalent in patients with SSc and MCTD,so it may be an early predictor of pulmonary involvement in patients with SSc or MCTD.
