Research on the relation between upper gastrointestinal bleeding and non-steroidal anti-inflammatory drugs

VernacularTitle:非甾体抗炎药致上消化道出血的相关性研究
Author: Shaofeng HE ; Wenyang XIA ; Jian GUO
Publication Type:Journal Article
Keywords: Anti-inflammatory agents,non-steroidal; Upper gastrointestinal bleeding
From: Chinese Journal of Postgraduates of Medicine 2010;33(4):33-35
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical features and the correlated reason of upper gastrointestinal bleeding (UGIB) induced by non-steroidal anti-inflammatory drugs (NSAIDs). Methods Five hundred and twenty-eight patients were divided into two groups according to consumption of NSAIDs in the week previous to the onset of bleeding, 116 cases were in NSAIDs group and 412 cases were in non-NSAIDs group. The clinical data was analysed and compared between two groups. Results There was no significant difference in sex, smoking history, and ulcer history between two groups (P> 0.05). The average age was (57.4 ± 12.1) years old and the infection of Hp was 65.5% (76/116) in NSAIDs group, and they were higher than those in non-NSA1Ds group [(44.6 ± 11.9) years old and 25.0% (103/412)](P < 0.01). More gastric ulcer and complex ulcer was seen in NSAIDs group (P <0.01 or <0.05). Conclusion Recognition about the clinical characteristics of NSAIDs relevance UGIB should be strengthened, and side effect of NSAIDs should be reduced as far as possible.