Effects of IL-6,TNF-α in Patients with different kinds of coronary heart disease

VernacularTitle:白介素-6和肿瘤坏死因子在不同类型冠心病中的作用探讨
Author: Lianjie LV ; Guangchun WANG
Publication Type:Journal Article
Keywords: Coronary disease; Interleukin-6(IL-6); Tumor necrosis factor-α
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(12):2146-2147
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of IL-6,TNF-α in patients with different kinds of coronary heart disease(CHD) and their clinical significance.Methods Totally 30 patients with acute myocardial infarction (AMI),30 cases with unstable angina pcctoris(UAP) and 25 cases with stable angina pectoris(SAP) were enrolled as the subjects,with 20 subjects with no coronary heart disease as controls.The serum concentrations of IL-6 and TNF-α were measured,and the results were analyzed and compared.Results Compared with SAP group and control group,the serum concentrations of IL-6 and TNF-α in AMI group and UAP group were significantly increased (P＜0.01).Compared with UAP group,the serum concentrations of IL-6 and TNF-α in AMI group were statistically higher(P＜0.05).Conclusion The inflammatory reaction induced by IL-6 may take part in the vulnerability and rupture of atheromatous plaque;TNF-α may play an important role in promotion of AS development and instability of plaque.