The expression of DOG1 in gastrointestinal stromal tumors
10.3760/cma.j.issn.1007-631X.2010.01.015
- VernacularTitle:DOG1蛋白在胃肠道间质瘤中的表达及其意义
- Author:
Mujun YIN
;
Shan WANG
;
Shijie LI
;
Kewei JIANG
;
Yingjiang YE
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumors;
Tumor makers,biological;
Gene expression;
Pathology,clinical;
DOG1 protein
- From:
Chinese Journal of General Surgery
2010;25(1):44-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate DOG1 as an immunohistochemical marker for GIST.Methods From Jan 1987 to Sep 2008,210 consecutive cases including 137 GISTs as well as 73 non-GIST sarcoma were evaluated for clinicopathological characteristics and immunostained for DOG1 antibodies.Result Immunoreactivity for DOG1 was detected in 110 of 137 GIST cases (80.3%),3 out of 11 CD117negative GISTs were DOG1-positive.Only 1 of 73 non-GIST case was positive for DOG1.The expression of DOG1 in GIST is associated with the location of tumor,cell density,nuclear pleomorphism and Fletcher grading criteria.The postoperative 1-,3-,5-year overall survival for DOG1 negative and positive patients was 81.3%,74.5%,74.5% and 98.5%,85.9%,83.2%,respectively,P = 0.034.Conclusion DOG1 was a sensitive and specific marker for GIST in gastrointestinal mesenchymal tumors (GIMT).
