Effects of cilazapril on QT interval dispersion and ventricular arrhythmia in patients with essential hypertension

VernacularTitle:西拉普利对原发性高血压患者QT间期离散度及室性心律失常的影响
Author: Yafeng Lü
Publication Type:Journal Article
Keywords: Cilazapril; Essential Hypertension; QT dispersion; Ventvicular arrhythmla
From: Clinical Medicine of China 2010;26(2):118-120
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of cilazapril on heart rate corrected QT interval disoersion (QTcd) and ventricular arrhythmia (VA) in patients with essential hypertension. Methods 96 hypertensive patients with LVH were divided randomly into two groups. 48 patients in lercanidipine group were treated routinely plus lercanidipine. 48 patients in cilazapril group were treated with routine drugs plus cilazapril. QTcd of 12-lead sur-face ECC and VA malignant degree recorded by Holter were analyzed before therapy and 6 mgnths after therapy. Re-suits In the cilazapril group,the QTcd was different before and after the therapy ((76±12) ms vs (65±9) ms, P<0.05 ). In the lercanidipine group, the QTcd was not significantly different ((76±13 ) ms vs (74±12) ms, P > 0.05). QTed and the malignant degree of VA between the two groups were significantly different after the therapy. Conclusions Treatment with cilazapril can reduce the QTcd and the malignant degree of VA in hypertensive patients with LVH.