The protein expression of cyclinD1, p27 and p16 in the colorectal carcinoma
10.3760/cma.j.issn.1673-4904.2010.04.004
- VernacularTitle:细胞周期调控因子cyclinD1、p27、p16在大肠癌中的表达
- Author:
Yonghong SUN
- Publication Type:Journal Article
- Keywords:
Intestinal neoplasms;
Cyclin D1;
Immunohistochemistry
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(4):10-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and significance of cyclinD1, p27 and p16 in the genesis and progress of the colorectal carcinoma by analyzing their expression and their relation with clinicopathological parameters. Methods Immunohistochemistry one-step method was used to examine the expression of cyclinD1, p27 and p 16 respectively in 53 cases of colorectal carcinoma tissues and 30 cases of normal colorectal tissues. SPSS13.0 statistic software was used to analyze the correlation of their abnormal expressions to colorectal carcinoma. Results The positive expression rate of cyclinD1 was 64.15% (34/53) in the colorectal carcinoma tissues and 6.67% (2/30) in the normal colorectal tissues (P < 0.01). The positive expression rate of p27 was 30.19% (16/53) in the colorectal carcinoma tissues and 76.67% (23/30) in the normal colorectal tissues (P < 0.01). The positive expression rate of p 16 was 43.40% (23/53) in the colorectal carcinoma tissues and 83.33%(25/30) in the normal colorectal tissues (P < 0.01). Compared moderately and well differentiated carcinoma with poor differentiated carcinoma, each of these three indicators had significant difference (P <0.05). Compared with A+B stage and C+D stage in Dukes stage of colorectal carcinoma, each of these three indicators had significant difference(P < 0.05). Conclusions The changes of cyclinD1, p27 and p16 are related to the occurrence and malignant degree of colorectal carcinoma which can provide an important reference to the clinical biology manifestation and prognosis of the patients suffering from colorectal carcinoma.
