The change of plasm level of vascular endothelial growth factor in children anaphylactoid purpura

VernacularTitle:儿童过敏性紫癜血管内皮生长因子血浆含量变化
Author: Zhuo FU ; Shaomin REN
Publication Type:Journal Article
Keywords: Purpura,schoenlein-henoch; Children; Vascular endothelial growth factor
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(12):2171-2172
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between plasm level of vascular endothelial growth factor (VEGF) and children Anaphylactoid purpura(AP).Methods The concentrations of VEGF in serum were detected with enzyme-linked immunosorhent assay in twenty four children with AP,twenty four children with APN in acute phase and twenty four healthy children.Results The concentrations of VEGF in patients with APN in acute phase,AP and normal control was (244.56±51.12)μg/L,(155.71±50.48)μg/L and (54.91±40.07)μg/L,respectively.Plasma levels of VEGF in children with APN and AP were significantly higher than those in normal control,statistically significant difference was observed (F=95.789,P=0.000＜0.01).Conclusion The concentrations of VEGF in serum increases markedly in acute phase of AP,those in APN is higher than in AP.It indicated that VEGF involved in the occurrence and development of AP vaseulitis,and may reflect the extent of pathogenetic condition.