Study of HIF-1α,iNOS and hemodynamic in patients with hepatopulmonary syndrome with portal hypertension
10.3760/cma.j.issn.1008-6706.2010.02.001
- VernacularTitle:肝肺综合征患者缺氧诱导因子-1α和诱导型一氧化氮合酶水平与门脉高压血流动力学的关系
- Author:
Hong MA
;
Xin ZHAO
;
Yanying WANG
;
Yanxia ZHANG
;
Yanfeng WANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Hypoxia inducible factor-1α;
Inducible nitric oxide synthase;
Hepatopulmonary syndrome;
Intrapulmonary shunting
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(2):145-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the color doppler sonography and contrast-enhanced echocardiography(CEE)in assessment of intrapulmonary shunting in patients with hepatopulmonary syndrome and HIF-1α,iNOS and portal hemodynamic.Methoods To examine the portal vein diameter and blood flow velocity by color Dop-pler,and intrapulmonary shunting by contrast-enhanced echocardiography(CEE).The expressions of HIF-1α and iNOS in serum were determined by ELISA in the normal,hepatocirrhosis amalgamating HPS and unamalgamating HPS separately.Comparison of HIF-1α and iNOS in plasma was carried out and relationship between the portal hemodynamic and the intra-pulmonary shunting was examined in three groups.Results The levels of HIF-1α and iNOS in hepatocirrhosis amalgamating HPS were higher than those in unamalgamating HPS,the diameter of portal vein dilated and the velocity of portal vein dropped,there was correlation(P＜0.05).There were positive correlation with intrapulmonary shunting.Conclusion The color doppler sonography and contrast-enhanced echocardiography (CEE)which reflected HIF-1α,iNOS and the hemodynamic played an role in developing of HPS,and was available to early examine change of intra-pulmonary vessel.
