Correlations of fundus lesions with prognostic significance in acute leukemia

VernacularTitle:急性白血病眼底改变与预后的关系
Author: Xinyu CUI
Publication Type:Journal Article
Keywords: Leukemia,lymphocytic,acute; Retinal diseases; Prognostic
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(10):1741-1742
CountryChina
Language:Chinese
Abstract: Objective To determine retinal charges in newly diagnosed acute leukemia patients and to eval-uate the diagnostic value of retinal findings in patients with central nervous systerm leukemia(CNSL) and intracranial hemorrhage(IH). Methods 123 patients with acute leukemia(86 had myeloid leukemia and 37 had lymphoid leuke-mia) aged 14～77 years were examined with direct/indirect ophthalmoscopy for the presence of intraretinal hemorrha-ges (IRH), white-centred hemorrhages (WCH) and cotton-wool spots (CWS) within 5 days of diagnosis. Results CNSL and IH were more common in patients with retinopathy than those without (27.1% vs 9.1%, P=0.046; 29.2% vs 9.1%, P=0.029;respectively). Complete remission(CR) rate in patients with IRH was lower than those without(52.5% vs 80.5%, P =0.08). No association was found between the presence of WCH or CWS and CR rate. Conclusion The present study shows that patients with IRH is an indicator of poor prognosis in acute leukemia. Leukemic retinopathy usually is seen in patients with IH. Invasion of the eye by leukemia is not rare and indicates the need for early ophthalmological examination.