Deanxit in adjuvant treatment of non-erosive reflux disease non-responding to proton pump inhibitor

VernacularTitle:氟哌噻吨美利曲辛辅助治疗质子泵抑制剂治疗无效的非糜烂性反流病
Author: Yanmin CHEN ; Jianjun ZHU
Publication Type:Journal Article
Keywords: Flupentixol; melitracen; Escmeprazole; Gastroesophageal refulx
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(10):1747-1748
CountryChina
Language:Chinese
Abstract: Objective To investigate the efficacy of flupentixol and melitracen(Deanxit) in treatment of non-erosive reflux disease(NERD) and non-responding to proton pump inhibitor. Methods Fifty eight NERD pa-tients were randomly divided into two groups, the treatment group (n = 29) and control group (n = 29). Patients in control group were given esomeprazole 40 mg qd. Patients in the treatment group were given the same drug plus Deanxit 1 Tab qd. The clinical effect was evaluated and scored by Hemihon Anxiety Rating Scale (HAMA) after 4 weeks. Results The total efficacy rate of the treatment group was higher than control group (P < 0.01),and HAMA was lower in the treatment group than in control group (P < 0.01). Conclusions Adjuvant treatment of Deanxit combined with esomeprazole is effective to NERD patients who did not respond to proton pump inhibitor, can greatly improve anxious disorders.