Loss of RASAL1:a new mechanism of ras activation in cancers
10.3760/cma.j.jssn.1673-422X.2009.11.003
- VernacularTitle:RASAL1蛋白丢失——恶性肿瘤中ras活化的新机制
- Author:
Qing YANG
;
Chengjia QIAN
- Publication Type:Journal Article
- Keywords:
ras protein;
ras GTPase-activating proteins;
Neoplasms
- From:
Journal of International Oncology
2009;36(11):809-811
- CountryChina
- Language:Chinese
-
Abstract:
Ras is a kind of protein closely related to neoplasms,the persistent activation of which would induce tumorigenesis and progression.RASAL1 is a Ca~(2+) regulated ras GTPase-activating-like protein, the loss or decreased expression of RASAL1 induces ras activation, then results in tumongenesis and progression.In this review we sum up the mechanism of ras activation, the relationship between neoplasms and RASAL1 and the mechanism of RASAL1 expression decreasing.
