Relationship of CDX1 mRNA and CDX2 mRNA expression and clinicopathologic features in colorectal cancers.
- Author:
Gwang Ha KIM
1
;
Dong Hyun LEE
;
Hyung Wook KIM
;
Jong Yun CHEONG
;
Soo Boon SEO
;
Jeong HEO
;
Dae Hwan KANG
;
Geun Am SONG
;
Mong CHO
;
Ung Suk YANG
;
Do Youn PARK
;
Mi Ae YOO
Author Information
1. Department of Internal Medicine, Pusan National University College of Medicine, Busan, Korea. doc0224@chollian.net
- Publication Type:Original Article
- Keywords:
Colorectal cancers;
Homeobox genes;
CDX1;
CDX2;
Expression
- MeSH:
Carcinoembryonic Antigen;
Colorectal Neoplasms*;
Genes, Homeobox;
Humans;
Lymph Nodes;
Mucous Membrane;
Neoplasm Metastasis;
Real-Time Polymerase Chain Reaction;
RNA, Messenger*
- From:Korean Journal of Medicine
2004;67(4):349-357
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: CDX1 and CDX2, members of the caudal-type homeobox gene family, control proliferation and differentiation of intestinal mucosal cells. Their expression is reduced commonly in colorectal cancers, but reports about the relationship between their expression and the clinicopathologic features are rare. The aim of this study was to examine CDX1 mRNA and CDX2 mRNA expression in colorectal cancers and to assess the relationship between their expression and the clinicopathologic features. METHODS: CDX1 mRNA and CDX2 mRNA expression were analyzed by real-time polymerase chain reaction in 48 colorectal cancers and their adjacent non-tumorous normal mucosas. RESULTS: CDX1 mRNA and CDX2 mRNA expression were decreased significantly in colorectal cancers than in normal mucosas (p=0.001, p=0.042, respectively). In comparison with paired normal mucosas, colorectal cancers showed decreased CDX1 mRNA expression in 64.6% (31/48) and decreased CDX2 mRNA expression in 66.7% (32/48). There was a statistically significant correlation between CDX1 mRNA and CDX2 mRNA expression in colorectal cancers (r=0.543, p<0.001). CDX1 mRNA and CDX2 mRNA expression were not related to age, sex, location of cancer, differentiation, lymphatic or vascular invasion, lymph node metastasis, stage and serum carcinoembryonic antigen level in colorectal cancers. CONCLUSION: CDX1 mRNA and CDX2 mRNA expression were decreased significantly in colorectal cancers, but were not related to the clininopathologic features.
