The effect of glucocorticoids in patients with acute exacerbation of severe COPD and its impacts on the serum levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase-1
10.3760/cma.j.issn.1008-6315.2010.01.016
- VernacularTitle:基质金属蛋白酶-9及其抑制剂在糖皮质激素治疗重度慢性阻塞性肺疾病急性加重期的变化及意义
- Author:
Peifang ZHANG
;
Zhiyang LUO
;
Lixian ZHENG
;
Zhanqiang MEI
;
Guocui ZHEN
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase 9;
Tissue inhibitor of metaUoproteinases;
Chronic obstructive pulmonary disease;
Glucocorticoids
- From:
Clinical Medicine of China
2010;26(1):38-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of matrix metalloproteinase 9(MMP-9)and tissue inhibitor of metalloproteinase-1(TIMP-1)in patients with acute exacerbation of severe chronic obstructive pulmonary diseases (AECOPD)treated with glucocorticoids.Methods The serum levels of MMP-9 and TIMP-1 were measured by ELISA in 41 patients with AECOPD before and after treatment with glucocorticoids and in 40 patients with regular methods(control group).Results ①After treatment with glucocorticoids,the serum levels of MMP-9(189.25±52.38)μg/L、TIMP-1(198.38±43.45)μg/L,ratio of MMP-9/TIMP-1(0.92±0.37)were decreased significantly than before((246.10±68.64)μg/L,(217.63±62.34)μg/L,(1.09±0.23))(P<0.01,P<0.05,P<0.05);but there were no differences(P>0.05)in regular methods(control group);② After treatment with glucoeorticoids, FEV_1、FEV_1%((0.83±0.35)L,(46±17)%)were impmved than before((0.72±0.48)L,(34±15)%)(P<0.05).Conclusions After treatment with glucocorticoids,the serum levels of MMP-9、TIMP-1、ratio of MMP-9/TIMP-1 from patients with COPD were decreased significandy,and FEV_1、FEV_1%were improved significant;Glucocorticoids can alleviate severs AECOPD to some degrees,which might be related to improving the imbalance of MMP-9/TIMP-1.
