Study of enzyme function on blood crystalloid cardioplegia at different flow continuous perfusion
10.3760/cma.j.issn.1673-4904.2010.06.007
- VernacularTitle:血晶心停跳液不同流量连续灌注对心肌的保护作用
- Author:
Ning LIU
- Publication Type:Journal Article
- Keywords:
Blood crystalloid cardioplegia;
High flow;
Minimum flow;
Myocardial zymogram
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(6):18-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of different flow volume of continuous 1:1 blood crystalloid cardioplegia on open heart surgery.Methods Retrospective randomized study was performed on 80 patients undergoing valve replacement and congenital heart disease with 1:1 blood crystalloid cardioplegia by minimum-flow continuous perfusion[0.5ml/(kg·min),group A,40 cases],high-flow continuous perfusion[(2.0 ml/(kg·min),group B,40 cases).The changes of creatine kinase(CK),isoenzyme of creatine kinase(CK-MB),lactate dehydrogenase(LDH),lactic dehydrogenase isoenzyme(LDH_1)were detected before operation and at 6,12,24,48,72 h after operation.Results The cardioplegia liquid was (41.72±7.98)ml/kg in group A,(142.09±9.65)ml/kg in group B,there was significant difference between two groups(P<0.05).During the first 72 h postoperative the value of CK,CK-MB,LDH and LDH1 in two groups were increased to different degree,serum enzymes levd increased significantly between 12,24 h after operation(P<0.05)and return to normal at 72h after operation in two groups.Butbetween two groups there was no significant difference(P＞0.05).ConclusionMinimum-flow continuous perfusion of 1:1 blood crystalloid cardioplegia appears to be superior in safety,decrease of myocardial enzymes integrity.
