Effect of estrogen and aspirin on proliferative stage of endometrium
10.3760/cma.j.issn.1673-4904.2010.06.008
- VernacularTitle:小剂量雌激素及阿司匹林对促排卵中增殖期子宫内膜的影响
- Author:
Xiaomu OU
;
Jingling WANG
;
Wei SHEN
- Publication Type:Journal Article
- Keywords:
Estrogens;
Endometrium;
Aspirin;
Clomiphene
- From:
Chinese Journal of Postgraduates of Medicine
2010;33(6):21-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effect of clomiphene citrate(CC)on the proliferative stage of endometrium by the addition of low-doge estrogen(progynova,PGV)and aspirin.Methods Sixty women with unexplained infertility were divided into 4 groups randomly.Untreated group,CC treated group(C group),CC+PGV treated group(CE group)and CC+PGV+aspirin treated group(CEA group),each group Was 15 cases.Endometrium thickness,pattern of endometrium and resistant index(RI)of uterine artery were detected by ultrasound,all at end proliferative stage of endometrium.Results The endometrium thickness,the rate of the endometrium thickness≥8 mm and the rate of A-endometrium in C group were significantly less than those in other 3 groups(P<0.05).The rate of A-endometrium in CE group was significantly less than that in untreated group and CEA group(P<0.05).The number of follicle diameter≥15 mm in untreated group(1.01±0.25)was signifieantly less than that in other 3 groups(1.56±0.64,1.52±0.70,1.61±0.67)(P<0.os).RI of uterine artery in C group(0.93±0.07)and CE group(0.95±0.04)were significantly higher than that in untreated group(0.81±0.05)and CEA group(0.83±0.03)(P<0.05).Conclusion Low-dese estrogen can reverse the deleterious effect of CC on.endometrial development,and low-dose estrogen and aspirin can promote uterine perfusion and improve uterine compatibility.
