The correlation between fraction of exhaled nitric oxide and lung function in asthmatic children
10.3760/cma.j.issn.1673-4912.2010.01.013
- VernacularTitle:哮喘患儿呼出气一氧化氮水平与肺功能相关性研究
- Author:
Nan YANG
;
Yunxiao SHANG
;
Linhua SHU
;
Jing FENG
- Publication Type:Journal Article
- Keywords:
Bronchial asthma;
Exhaled nitric oxide;
Lung function
- From:
Chinese Pediatric Emergency Medicine
2010;17(1):34-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between exhaled nitric oxide and lung function (FEV1)in asthmatic children.Methods Fifty three stable asthmatic children aged 5 to 14 years old were recruited from ShengJing Hospital of China Medical University.According to whether the patients were treated with inhaled corticosteroid(ICS)therapy regularly,they were divided into two groups:steroid group and non-steroid group,then fraction of exhaled nitric oxide(FeNO)and lung function were measured.Results In non-steroid group,the levels of FeNO(mean 40.450±25.428 part by billion)were significantly higher than those in the steroid group(mean 19.879±13.845 part by billion),and they were statistically significant.(P = 0.003).The mean FEVI in non-steroid group was(95.152±8.993)%,and the mean FEVI in non-steroid group was(91.350±11.690)%,and there were no significant differences between two groups (P =0.189).Significantly negative correlation was found between FeNO and FEV1 in steroid group(r =-0.465,P = 0.039),but there was no significant correlation between them in steroid group(r = 0.058,P =0.747).Conclusion The levels of FeNO were higher in non-steroid group than those of the steroid group in the stable asthmatic children.FeNO is a good biomarker to evaluate the airway inflammation of asthmatic children.
