Clinical significance of the changes of plasma homocysteine,endothelin,mononitrogen monoxide,folic acid and vitamine B_(12) in acute cerebral infarction
10.3760/cma.j.issn.1008-6706.2009.12.026
- VernacularTitle:急性脑梗死患者血浆同型半胱氨酸、内皮素、一氧化氮、叶酸、维生素B_(12)变化及临床意义
- Author:
Xiangjun WANG
;
Ancheng ZHAO
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Homocysteine;
Endothelin;
Vasoconstrictive peptide;
Mononitrogen monoxide;
Vitamine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(12):2160-2162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the fluctuations of homoeysteine(Hcy),endothelin(ET),mononitrogen monoxide(NO),folic acid(FA) and vitamine Bi2 (VitB_(12)) in the plasma of patients suffered from acute cerebral infarction and to investigate the clinical significance.Methods 140 blood specimens from cerebral infarction patients and 61 specimens from healthy individuals were obtained in this study and a series of items of Hey,ET,NO,FA and VitB_(12) were detected.Results The Hey [(17.15±4.63) μmol/L]and ET [(32.62±18.76) μmol/L]were increased in acute cerebral infarction(ACI) group compared with that in control group[(10.12±2.62) μmol/L,(20.08±13.38) μmol/L respectively]and the difference was significant (P＜0.01).The levels of NO [(39.82±7.26) μmol/L],FA [(7.54±4.01) ng/ml]and VitB_(12) [(247.70±119.85) pg/ml]were decreased compared with control group [(60.22±6.28) μmol/L,(10.08±3.86) ng/ml,(411.52±194.58) pg/ml respectively]and the differences significant (P＜0.01).Gender and hypertension affected the values of Hey.Conclusions Hcy and ET were increased while NO,FA and VitB_(12) were decreased in acute cerebral infarction.Hcy had positive correlation with ET and negative correlation with FA and VitB_(12).
