Association between the G20597A variant of CYP4F2 gene and essential hypertension

VernacularTitle:CYP4F2基因G20597A多态性与高血压病相关性研究
Author: Laxi ZHANG ; Jing YANG ; Fangfang SHEN ; Daowen WANG
Publication Type:Journal Article
Keywords: Cytochrome P-450 enzyme system/GE; Polymorphism,genetic; Hypertension/GE
From: Journal of Chinese Physician 2010;12(1):27-30
CountryChina
Language:Chinese
Abstract: Objective To analyze relationship between the gene polymorphism of CYP4F2 and essential hypertension (EH) in China's Han population. Methods 189 EH patients and 187 age-matched controls were used to analysis G20597A polymorphism site of CYP4F2 gene with polymerase chain-restriction fragment length polymorphisms. Results There was no difference of neither genotype nor allele of CYP4F2 (G20597A) between EH and controls through stratified analysis on gender. CYP4F2 gene 20597 G allele carriers had significant association with EH for male in China (81.6% vs 71.3% , P =0.019) , but not with female. After adjustment for cardiovascular risk factors (including smoking, TC, age, genetype, BMI) , the hazard ratio for incident EH in male with CYP4F2 20597GG increased about 2. 689 than that with CYP4F2 20597GA and 20597AA. Conclusion CYP4F2 20597G allele has significant association with male EH, and CYP4F2 20597GG may be an independent predictor of EH for male in china's Han population.