Effect of Rho-kinase inhibitor on experimental allergic neuritis

VernacularTitle:Rho激酶抑制剂对实验性变态反应性神经炎发病的影响
Author: Ning ZHANG ; Gang LI ; Bo XIAO ; Yunhai LIU ; Yan CAI ; Xingang SUN ; Jinghui LIANG
Publication Type:Journal Article
Keywords: rho-associated kinases/Al/PD; Neuritis,autoimmune,experimental/DT
From: Journal of Chinese Physician 2010;12(1):47-50
CountryChina
Language:Chinese
Abstract: Objective To study the effect of Rho-kinase inhibitor on experimental allergic neuritis. Methods 54 female Lewis rats were divided into three groups; EAN group, EAN + Rho-kinase inhibitor group, and CFA group. The rats were sacrificed on the 9th day, 17th day, and 26th day after immunized. The changes of weight, EAN incidence, and mean day of onset, mean maximum clinical score, and histopa-thology were observed. Results The clinical course in EAN group reached peak on the 17th day. Compared with EAN group, the weights of Rho - kinase inhibitor group were increased, while EAN incidence, mean day of onset delay, and the clinical scores in Rho-kinase inhibitor group were significantly decreased, ( P < 0.01) , and the demyelization and inflammation cells infiltrating was ameliorated in spinal nerve. CFA group didnt show any clinical manifestation. Conclusions Rho - kinase inhibitor may ameliorate the development of EAN through inhabiting the Rho/ROK signal pathway.