Metabolize characteristic and effects of cephalosporins and fluoroquinolones in ACST in human bile

VernacularTitle:部分抗生素在急性梗阻性化脓性胆管炎患者胆汁中代谢特点及意义
Author: Dayong SUN ; Yagang ZHAO ; Hong SONG ; Meihua ZHOU ; Haiping ZENG
Publication Type:Journal Article
Keywords: Cephalosporins/PK; Quinolones/PK; Cholaiigjtia/DT
From: Journal of Chinese Physician 2010;12(1):68-70
CountryChina
Language:Chinese
Abstract: Objective To investigate the regulation of metabolize characteristic of some antibiotics in ACST in human bile, and provide the theoretic basis for physician selecting antibiotic rationally when biliary tract has been infected. Methods Samples of ACST in human bile were obtained by ERCP + ENBD, contents of Cefradine, Cefoperazone, Ceftriaxone, Ciprofloxacin and Lomefloxacin in human bile were simultaneously measured by HPLC method. Results After antibiotics were given through iv 0. 25 ～ 1. 5 hour, an increase was observed in contents of all antibiotics in bile, and the changes of Ceftriaxone and Ciprofloxa-cin were the most significant ( P <0.01). Ceftriaxone and Ciprofloxacin had a higher Cmax than other antibiotics, and Cefoperazone had a longer tl/2. Conclusion As maintaining a little time to tmax , a higher Cmax and a longer tl/2 in the bile by iv, Cefradine and Ciprofloxacin are recommended in the patient with ACST.